Psoriasis, Third Edition, (Basic and Clinical Dermatology) by Henry Roenigk


595868be43cc45b-261x361.jpg Author Henry Roenigk
Isbn 9780824701086
File size 23MB
Year 1998
Pages 880
Language English
File format PDF
Category medicine



 

< previous page page_aa next page > Page aa Psoriasis < previous page page_aa next page > < previous page page_ab next page > Page ab BASIC AND CLINICAL DERMATOLOGY Series Editors ALAN R. SHALITA, M.D. Professor and Chairman Department of Dermatology State University of New York Health Science Center at Brooklyn Brooklyn, New York DAVID A. NORRIS, M.D. Director of Research Professor of Dermatology The University of Colorado Health Sciences Center Denver, Colorado 1. Cutaneous Investigation in Health and Disease: Noninvasive Methods and Instrumentation, edited by Jean-Luc Lévêque 2. Irritant Contact Dermatitis, edited by Edward M. Jackson and Ronald Goldner 3. Fundamentals of Dermatology: A Study Guide, Franklin S. Glickman and Alan R. Shalita 4. Aging Skin: Properties and Functional Changes, edited by Jean-Luc Lévêque and Pierre G. Agache 5. Retinoids: Progress in Research and Clinical Applications, edited by Maria A. Livrea and Lester Packer 6. Clinical Photomedicine, edited by Henry W. Lim and Nicholas A. Soter 7. Cutaneous Antifungal Agents: Selected Compounds in Clinical Practice and Development, edited by John W. Rippon and Robert A. Fromtling 8. Oxidative Stress in Dermatology, edited by Jürgen Fuchs and Lester Packer 9. Connective Tissue Diseases of the Skin, edited by Charles M. Lapière and Thomas Krieg 10. Epidermal Growth Factors and Cytokines, edited by Thomas A. Luger and Thomas Schwarz 11. Skin Changes and Diseases in Pregnancy, edited by Marwali Harahap and Robert C. Wallach 12. Fungal Disease: Biology, Immunology, and Diagnosis, edited by Paul H. Jacobs and Lexie Nall 13. Immunomodulatory and Cytotoxic Agents in Dermatology, edited by Charles J. McDonald 14. Cutaneous Infection and Therapy, edited by Raza Aly, Karl R. Beutner, and Howard I. Maibach 15. Tissue Augmentation in Clinical Practice: Procedures and Techniques, edited by Arnold William Klein 16. Psoriasis: Third Edition, Revised and Expanded, edited by Henry H. Roenigk, Jr., and Howard I. Maibach ADDITIONAL VOLUMES IN PREPARATION < previous page page_ab next page > < previous page page_i next page > Page i Psoriasis Third Edition, Revised and Expanded edited by Henry H. Roenigk, Jr. Northwestern University Medical School Chicago, Illinois Howard I. Maibach University of California School of Medicine San Francisco, California MARCEL DEKKER, INC. NEW YORK BASEL HONG KONG < previous page page_i next page > page_ii < previous page next page > Page ii ISBN: 0-8247-0108-9 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel: 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 44-61-261-8482; fax: 44-61-261-8896 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright © 1998 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA < previous page page_ii next page > < previous page page_iii next page > Page iii SERIES INTRODUCTION During the past decade there has been a vast explosion in new information relating to the art and science of dermatology as well as fundamental cutaneous biology. Furthermore, this information is no longer of interest only to the small but growing specialty of dermatology. Scientists from a wide variety of disciplines have come to recognize both the importance of skin in fundamental biological processes and the broad implications of understanding the pathogenesis of skin disease. As a result, there is now a multidisciplinary and worldwide interest in the progress of dermatology. With these factors in mind, we have undertaken a series of books specifically oriented to dermatology. The series has been purposely broad in focus and has ranged from pure basic science to practical, applied clinical dermatology. Thus, while there is something for everyone, all editions in the series should ultimately prove to be valuable additions to the dermatologist's library. It is an honor and privilege to add the third edition of Henry H. Roenigk, Jr., and Howard I. Maibach's Psoriasis to our series. This outstanding text involves well-known authors throughout the world and addresses both basic science as well as clinical aspects of this troublesome disease. It has become the reference standard for authoritative discussion of psoriasis and should prove to be a valuable addition to the libraries of clinicians and researchers. ALAN R. SHALITA SUNY HEALTH SCIENCE CENTER BROOKLYN, NEW YORK < previous page page_iii next page > < previous page page_v next page > Page v PREFACE The third edition of Psoriasis has been significantly expanded and contains much new and innovative information. The first edition, published in 1985, contained 56 chapters. The third edition, which now contains 73 chapters, has a more condensed and compact clinical section and a broader view of the therapeutic options for psoriasis. A great deal of new information from the field of molecular biology has begun to assist our understanding of the mechanisms that produce and flare psoriasis. One area that has undergone dramatic development since the second edition is genetics. This new field explores the epidemiology of psoriasis. There are several conflicting conclusions in this area, and we have tried to present all views. It is hoped that genetics will result in the final cure for psoriasis. We have extensively updated the chapters on former therapies. For example, there are now new guidelines on methotrexate, with less need for liver biopsies. There are newer systemic retinoids with shorter half-lives. Cyclosporin is used more, and a new preparation with better absorption is available. Topical vitamin D therapy has also found a significant place in the therapy of psoriasis. While PUVA therapy is still being used to treat psoriasis, the recent finding of increased incidence of malignant melanoma from the 16-center PUVA follow-up study has caused some concern. Section VIII, New Treatments and Innovations, contains information on new therapies that are still in the developmental stages. Many of these therapies have not yet been approved. Newer topical retinoids have just been approved and seem helpful in stable plaque disease. New systemic cyclosporin and vitamin D products have also proven effective in large trials. New topical immunosuppressive agents will be safe and effective. The work with DAB-389 has given insight into the pathogenesis of psoriasis, as well as providing different forms of therapy. And the pharmaceutical industry is continually generating new ideas for psoriasis therapy. Finally, the physician, as well as organizations such as the National Psoriasis Foundation, is key in giving the emotional support necessary for the patient to deal with this disfiguring disease. Physicians need to spend more time dealing with quality of life issues that face the patient. This is sometimes difficult in an era of managed care. This book is intended for the practicing physician, whether internist, rheumatologist, family physician, pediatrician, dermatologist, or resident. Each chapter attempts to convey all new information in a way that enables the reader to develop a solid understanding of how to properly treat and advise patients about psoriasis. Psoriasis should prove to be a key reference book for anyone treating patients with this disease. We would like to express our deep appreciation to our extensive collection of international contributors, who have lent their expertise in the development of this text. Coordinating text and < previous page page_v next page > < previous page page_vi next page > Page vi meeting deadlines is not always an easy task. We aspire to update this volume every 5 years, so as to keep this publication current and beneficial to the reader. We will be back in 2003. HENRY H. ROENIGK, JR. HOWARD I. MAIBACH < previous page page_vi next page > < previous page page_vii next page > Page vii CONTENTS Series Introduction iii Preface v Contributors xiii I. Clinical Features 1. Skin Manifestations of Psoriasis and Eczematous Psoriasis: Maturation Henry H. Roenigk, Jr., Ernst Epstein, and Howard I. Maibach 3 2. Pustular Psoriasis: Generalized and Localized Smita Amin and Howard I. Maibach 13 3. The Nails Richard K. Scher 41 4. Scalp and Hair, Palms and Soles Janice Matsunaga, Howard I. Maibach, and Ernst Epstein 45 5. Photosensitive Psoriasis Anne-Marie Ros and Göran Wennersten 59 6. Human Immunodeficiency Virus and Psoriasis Joanna Badger, Timothy G. Berger, Charles Gambla, and John Y.M. Koo 65 7. Psoriatic Arthritis Eva Zachariae and Hugh Zachariae 75 8. Psychological Aspects of Psoriasis Mark D.P. Davis and Marian T. McEvoy 97 II. Incidence and Genetics 9. Epidemiology: Natural History and Genetics Eugene M. Farber and Lexie Nall < previous page 107 page_vii next page > page_viii < previous page next page > Page viii 10. Psoriasis Type I and Type II as Subtypes of Nonpustular Psoriasis Tilo Henseler and Enno Christophers 159 11. Population Genetics of Psoriasis Gunnar Swanbeck, A. Inerot, T. Martinsson, and J. Wahlström 167 12. Genes in Psoriasis Jayant Bhalerao, Alan K. Silverman, M. Alan Menter, and Anne M. Bowcock 177 III. Pathogenesis 13. Overview of Immunology Hachiro Tagami and Setsuya Aiba 191 14. The Polymorphonuclear Leukocytes Peter C.M. van de Kerkhof 209 15. Keratinocyte Abnormalities and Signaling Pathways Mark R. Pittelkow 225 16. Cell Proliferation Kinetics Gerald D. Weinstein, Ross S. Kaplan, and Jerry L. McCullough 247 17. The Langerhans Cell Marek Haftek 263 18. The Cell Membrane in Psoriasis Jonathan Mansbridge and Vera B. Morhenn 287 19. Pathogenic Interactions of Keratinocytes and T Lymphocytes in Psoriasis James G. Krueger 315 20. Chemokines Jens-Michael Schröder 329 21. Immunological Pathways in Psoriasis Christopher E.M. Griffiths 341 22. Molecular and Immunological Aspects of Psoriasis Madeleine Duvic and Noreen Lemak 349 23. Cytokine Abnormalities in the Epidermis Lloyd E. King, Jr., Lillian B. Nanney, and John Paul Sundberg 357 24. Anti-Infectious Therapy of Psoriasis E. William Rosenberg, Robert B. Skinner, Jr., and Patricia W. Noah 373 IV. Histology 25. Neuropeptides and Neurogenic Inflammation in Psoriasis Siba Prasad Raychaudhuri and Eugene M. Farber < previous page page_viii 383 next page > < previous page page_ix next page > Page ix 26. Neuropeptides and Psoriasis Carlo Pincelli 393 27. Microcirculation Irwin M. Braverman 399 28. Histopathology and Electron Microscopy of Psoriasis Sven Krengel, Gundula M. Schaumburg-Lever, Christoph C. Geilen, and Constantin 409 E. Orfanos V. Topical Therapy 29. Product Development for Psoriasis: Clinical Challenges and Opportunities Alice Bendix Gottlieb 421 30. Dithranol (Anthralin) Stefan Kraft, Howard I. Maibach, and Braham Shroot 435 31. Topical Corticosteroids Smita Amin, Roger C. Cornell, Richard B. Stoughton, and Howard I. Maibach 453 32. Goeckerman Therapy Lawrence E. Gibson and Harold O. Perry 469 33. Ambulatory Treatment Centers: United States Experience Nicholas J. Lowe and Pamela S. Lowe 479 34. Occlusive Therapy of Psoriasis Joseph B. Bikowski, Jr. 483 35. Vitamin D: Rationale and Potential Mechanism of Action Elke M.G.J. de Jong and Ole Baadsgaard 489 36. Vitamin D Analogues in the Treatment of Psoriasis John Y.M. Koo and John Siebenlist 497 37. Clinical Experience with Vitamin D Analogues David J. Hecker and Mark Lebwohl 507 38. Combination Therapies: Dovonex and Phototherapy Alan K. Silverman and M. Alan Menter 511 39. Safety of and Skin Irritation with Vitamin D Jørgen Serup 519 VI. Phototherapy 40. UVB Phototherapy Charles R. Taylor, Elissa J. Liebman, and Bernhard Ortel < previous page page_ix 529 next page > < previous page page_x next page > Page x 41. Oral Psoralen Photochemotherapy Bernhard Ortel, Elissa J. Liebman, Herbert Hönigsmann, and Charles R. Taylor 543 42. Hand and Foot PUVA Torkel Fischer 559 43. Topical PUVA and Bath PUVA Torkel Fischer 565 44. PUVA and Skin Cancer Henry H. Roenigk, Jr. 577 45. Combination and Rotational Therapy for Psoriasis Henry H. Roenigk, Jr. 587 46. Climatotherapy of Psoriasis Louis Weinrauch 593 VII. Systemic Therapy 47. Systemic Corticosteroids Arto Lahti and Howard I. Maibach 599 48. Topical Corticosteroid Occlusion Therapy: Psoriasis Yung-Hian Leow and Howard I. Maibach 603 49. Methotrexate Henry H. Roenigk, Jr., and Howard I. Maibach 609 50. Hydroxyurea Stephen Wright and Brian Gemzik 631 51. 6-Thioguanine Herschel S. Zackheim, Richard G. Glogau, David A. Fisher, and Howard I. Maibach 637 52. Cyclosporin for the Treatment of Psoriasis John Y.M. Koo, Charles Gambla, and Jaeho Lee 641 53. Long-Term Use of Cyclosporin in Dermatology Hugh Zachariae 659 54. Clinical Use of Etretinate and Acitretin Michael T. Goldfarb and Charles N. Ellis 663 55. Acitretin and Etretinate: Strategy for Use and Long-Term Side Effects Carle Paul and Louis Dubertret 671 56. Clinical Pharmacology of Acitretin Ulf W. Wiegand, R.C. Chou, and Alice Bendix Gottlieb 685 < previous page page_x next page > < previous page page_xi next page > Page xi 57. Retinoid Combinations Charles Grupper and Bruno Berretti 697 VIII. New Treatments and Innovations 58. Bioengineering and Psoriasis Enzo Berardesca, F. Distante, and Howard I. Maibach 707 59. Pharmacological Models for Psoriasis Syndromes Saqib J. Bashir and Howard I. Maibach 715 60. Psoriasis Small Plaque Assay for Assessment of Topical Drug Activity Antti I. Lauerma and Howard I. Maibach 727 61. Topical Retinoids Gerald D. Weinstein and Roshantha A.S. Chandraratna 731 62. Tacrolimus (FK506) in the Treatment of Psoriasis Jan D. Bos 743 63. Clinical Use of Oral 1,25-Dihydroxyvitamin D3 (Calcitriol) for the Treatment of Psoriasis and Psoriatic Arthritis 749 Michael F. Holick 64. Photodynamic Therapy of Psoriasis Jerry L. McCullough and Gerald D. Weinstein 757 65. Antithyroid Thioureylenes in Psoriasis Alan Elias and Ronald Barr 761 66. Ascomycins Maximilian Grassberger, Josef G. Meingassner, Anton Stütz, Klemens Rappersberger, and Klaus Wolff 769 67. Purine Nucleoside Phosphorylase Inhibition: A Novel Therapy for Psoriasis Gerald M. Walsh, George A. Omura, John A. Montgomery, Thomas J. Franz, Tacey X. Viegas, William J. Cook, Shanta Bantia, Narra Reddy, W. Mitchell Sams, Jr., 781 Alfred A. Bartolucci, and Howard I. Maibach 68. Potential Clinical Uses for Parathyroid Hormone-Related Peptide Analogues for Treating Psoriasis and Other Skin Disorders 789 Michael F. Holick 69. DAB389 IL-2: A Lymphocyte-Targeted Fusion Toxin James G. Krueger 795 70. Surgical Treatment of Psoriasis Michael H. Gold and Henry H. Roenigk, Jr. 801 < previous page page_xi next page > < previous page page_xii next page > Page xii IX. Patient Involvement in Psoriasis 71. Nursing for Psoriasis Joan L. Shelk 807 72. Using Art Therapy in the Treatment of Psoriasis: A Pilot Study Ruth S. Lewis 815 73. The National Psoriasis Organization: A Means to Educate and Advocate Gail M. Zimmerman 833 Index 837 < previous page page_xii next page > < previous page page_xiii next page > Page xiii CONTRIBUTORS Setsuya Aiba, M.D., Ph.D. Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan Smita Amin, M.D., F.R.C.P.(C) Department of Medicine, The Toronto Hospital, Western Division, University of Toronto, Toronto, Ontario, Canada Ole Baadsgaard, M.D. Department of Dermatology, University of Copenhagen, Gentofte Hospital, Copenhagen, Denmark Joanna Badger, M.D. Department of Dermatology, University of California Medical Center, San Francisco, California Shanta Bantia, Ph.D. University of Alabama, Birmingham, Alabama Ronald Barr University of California, Irvine, California Alfred A. Bartolucci, Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Saqib J. Bashir University of California School of Medicine, San Francisco, California Enzo Berardesca, M.D. Department of Dermatology, University of Pavia, Pavia, Italy Timothy G. Berger, M.D. Department of Dermatology, University of California Medical Center, San Francisco, California Bruno Berretti, M.D. Department of Dermatology, Polyclinique d'Aubervilliers, Aubervilliers, France Jayant Bhalerao, Ph.D. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas Joseph B. Bikowski, Jr., M.D. Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania < previous page page_xiii next page > < previous page page_xiv next page > Page xiv Jan D. Bos, M.D., Ph.D., F.R.C.P. Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Anne M. Bowcock, Ph.D. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas Irwin M. Braverman, M.D. Yale University School of Medicine, New Haven, Connecticut Roshantha A.S. Chandraratna, Ph.D. Retinoid Research, Allergan, Inc., Irvine, California R.C. Chou Clinical Pharmacology, F. Hoffmann-La Roche, Ltd., Basel, Switzerland Enno Christophers, M.D. Department of Dermatology, University of Kiel, Kiel, Germany William J. Cook, M.D., Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Roger C. Cornell, M.D. Department of Dermatology, Scripps Clinic and Research Foundation, La Jolla, California Mark D.P. Davis, M.D. Mayo Graduate School of Medicine, Rochester, Minnesota Elke M.G.J. de Jong University Hospital Nijmegen, Nijmegen, The Netherlands F. Distante, M.D. Department of Dermatology, University of Pavia, Pavia, Italy Louis Dubertret Dermatologie, Hôpital Saint Louis, Paris, France Madeleine Duvic, M.D. Department of Dermatology, M.D. Anderson Cancer Center, Houston, Texas Alan Elias University of California, Irvine, California Charles N. Ellis, M.D. Department of Dermatology, University of Michigan, Ann Arbor, Michigan Ernst Epstein University of California School of Medicine, San Francisco, California Eugene M. Farber, M.D. Psoriasis Research Institute, Palo Alto, California Torkel Fischer, M.D. National Institute for Working Life, Solna, Sweden David A. Fisher Department of Dermatology, University of California, San Francisco, California Thomas J. Franz, M.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Elaine Fuchs University of Chicago Medical Center, Chicago, Illinois Charles Gambla, M.D. Department of Dermatology, University of California Medical Center, San Francisco, California Christoph C. Geilen Free University, Berlin, Germany Brain Gemzik Research Division, Abbott Laboratories, Chicago, Illinois < previous page page_xiv next page > < previous page page_xv next page > Page xv Lawrence E. Gibson, M.D. Department of Dermatology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota Richard G. Glogau Department of Dermatology, University of California, San Francisco, California Michael H. Gold, M.D.* Northwestern University Medical School, Chicago, Illinois Michael T. Goldfarb, M.D. Department of Dermatology, University of Michigan, Ann Arbor, Michigan Ernesto Gonzalez, M.D. Newtonville, Massachusetts Alice Bendix Gottlieb, M.D., Ph.D. Clinical Research Center and Division of Clinical Pharmacology, University of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical School, New Brunswick, New Jersey Maximilian Grassberger Novartis Research Institute, Vienna, Austria Christopher E.M. Griffiths, M.D., F.R.C.P. Department of Dermatology, University of Manchester, Manchester, England Charles Grupper Department of Dermatology, Polyclinique d'Aubervilliers, Aubervilliers, France Marek Haftek, M.D., Ph.D. INSERM Unit 346/CNRS, Edouard Herriot Hospital, Lyon, France David J. Hecker, M.D. Department of Dermatology, Mount Sinai School of Medicine, New York, New York Tilo Henseler, M.D., Ph.D. Laboratory for Epidemiology and Genetics, Department of Dermatology, University of Kiel, Kiel, Germany Michael F. Holick, M.D., Ph.D. Department of Medicine, Boston University Medical Center, Boston, Massachusetts Herbert Hönigsmann, M.D. Department of Dermatology, University of Vienna Medical School, Vienna, Austria A. Inerot Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden Ross S. Kaplan University of California School of Medicine, Irvine, California Lloyd E. King, Jr., M.D., Ph.D. Department of Medicine, Vanderbilt University School of Medicine, and Department of Dermatology, Department of Veterans Affairs Medical Center, Nashville, Tennessee John Y.M. Koo, M.D. Psoriasis Treatment Center, Department of Dermatology, University of California Medical Center, San Francisco, California Stefan Kraft Department of Dermatology, Ludwig Maximilians University, Munich, Germany *Current affiliation: Gold Skin Care Center, Nashville, Tennessee. < previous page page_xv next page > < previous page page_xvi next page > Page xvi Knud Kragballe, M.D., Ph.D. Marselisborg Hospital, Aarhus, Denmark Sven Krengel Free University, Berlin, Germany James G. Krueger, M.D., Ph.D. Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York Arto Lahti University of Oulu, Oulu, Finland Antti I. Lauerma, M.D., Ph.D. Department of Dermatology, University of Helsinki, Helsinki, Finland Mark Lebwohl, M.D. Department of Dermatology, Mount Sinai School of Medicine, New York, New York Jaeho Lee Department of Dermatology, University of California Medical Center, San Francisco, California Noreen Lemak, M.D. Department of Dermatology, University of Texas Medical School, Houston, Texas Yung-Hian Leow University of California School of Medicine, San Francisco, California Ruth S. Lewis School of the Art Institute of Chicago, Chicago, Illinois Elissa J. Liebman Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts Nicholas J. Lowe, M.D. Southern California Dermatology and Psoriasis Center, Santa Monica, and UCLA School of Medicine, Los Angeles, California Pamela S. Lowe, RPT Southern California Dermatology and Psoriasis Center, Santa Monica, California Howard I. Maibach, M.D. University of California School of Medicine, San Francisco, California Jonathan Mansbridge, Ph.D. Advanced Tissue Sciences, La Jolla, California T. Martinsson Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden Janice Matsunaga, M.D. Associate Clinical Professor, Section of Dermatology, John A. Burns School of Medicine, Honolulu, Hawaii Jerry L. McCullough, M.D. Department of Dermatology, University of California School of Medicine, Irvine, California Marian T. McEvoy, M.D., M.R.C.P., F.A.C.P. Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota Josef G. Meingassner Novartis Research Institute, Vienna, Austria M. Alan Menter, M.D. Psoriasis Center, Baylor University Medical Center, Dallas, Texas John A. Montgomery, Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama < previous page page_xvi next page > < previous page page_xvii next page > Page xvii Vera B. Morhenn, M.D. Department of Dermatology, University of California, San Diego, California Lexie Nall, M.D. Epidemiology Laboratory, Stanford University School of Medicine, Stanford, California Lillian B. Nanney, Ph.D. Department of Plastic Surgery & Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee Patricia W. Noah, Ph.D. Department of Medicine, University of Tennessee, Memphis, Tennessee George A. Omura, M.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Constantin E. Orfanos, M.D. Department of Dermatology and Venerology, Free University, Berlin, Germany Bernhard Ortel, M.D. Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts Carle Paul Hôpital Saint Louis, Paris, France Harold O. Perry, M.D. Mayo Clinic and Mayo Medical School, Rochester, Minnesota Carlo Pincelli, M.D. Department of Dermatology, University of Modena, Modena, Italy Mark R. Pittelkow, M.D. Departments of Dermatology, and Biochemistry and Molecular Biology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota Klemens Rappersberger Department of Dermatology, Vienna General Hospital, Vienna, Austria Siba Prasad Raychaudhuri, M.D. Psoriasis Research Institute, Palo Alto, California Narra Reddy, Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Henry H. Roenigk, Jr., M.D. Department of Dermatology, Northwestern University Medical School, Chicago, Illinois Anne-Marie Ros, M.D., Ph.D. Department of Dermatology, Karolinska Hospital, Stockholm, Sweden E. William Rosenberg, M.D. Department of Medicine, University of Tennessee, Memphis, Tennessee W. Mitchell Sams, Jr., M.D. University of Alabama, Birmingham, Alabama Gundula M. Schaumburg-Lever, M.D. Department of Dermatology, Eberhard Karls University, Tübingen, Germany Richard K. Scher, M.D., F.A.C.P. Professor, Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York Jens-Michael Schröder, Ph.D. Department of Dermatology, University of Kiel, Kiel, Germany Jørgen Serup, M.D., Ph.D. Director, Department of Pharmaceutical Research, Leo Pharmaceutical Products, Copenhagen, Denmark < previous page page_xvii next page > page_xviii < previous page next page > Page xviii Joan L. Shelk Leone Dermatology Center, Arlington Heights, Illinois Braham Shroot, Ph.D. Centre International de Recherches Dermatologiques, Sophia-Antipolis, France John Siebenlist, M.D. Department of Dermatology, University of Texas, San Antonio, Texas Alan K. Silverman, M.D. Professional Practice, Dallas, Texas Robert B. Skinner, Jr., M.D. Department of Medicine, University of Tennessee, Memphis, Tennessee Richard B. Stoughton, M.D. Department of Dermatology, University of California School of Medicine, San Diego, California Anton Stütz Novartis Research Institute, Vienna, Austria John Paul Sundberg, D.V.M., Ph.D. The Jackson Laboratory, Bar Harbor, Maine Gunnar Swanbeck, M.D., Ph.D. Department of Dermatology, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden Hachiro Tagami, M.D., Ph.D. Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan Charles R. Taylor, M.D. Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts Peter C.M. van de Kerkhof, M.D., Ph.D. Department of Dermatology, University of Nijmegen Hospital, Nijmegen, The Netherlands Tacey X. Viegas, Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama J. Wahlström Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden Gerald M. Walsh, Ph.D. BioCryst Pharmaceuticals, Inc., Birmingham, Alabama Louis Weinrauch, M.D. Bell Dermatology Associates, Jerusalem, Israel Gerald D. Weinstein, M.D. Department of Dermatology, University of California School of Medicine, Irvine, California Göran Wennersten, M.D., Ph.D. Associate Professor, Department of Dermatology, Karolinska Hospital, Stockholm, Sweden Ulf W. Wiegand Clinical Pharmacology, F. Hoffmann-La Roche, Ltd., Basel, Switzerland Klaus Wolff, M.D. Department of Dermatology, Vienna General Hospital, Vienna, Austria Deceased. < previous page page_xviii next page >

Author Henry Roenigk Isbn 9780824701086 File size 23MB Year 1998 Pages 880 Language English File format PDF Category Medicine Book Description: FacebookTwitterGoogle+TumblrDiggMySpaceShare Broadening the topics that earned the Second Edition a reputation as the premier reference of its kind, Psoriasis, Third Edition, incorporates the most recent innovations and experimental therapies to create an even more comprehensive source of information on all aspects of this problematic disease. Features new information concerning bioengineering and psoriasis topical retinoids FK 506 photodynamic therapy ascomycin derivatives PH5T inhibitors DAP-389 therapy and more! Completely updated with the latest developments in areas such as neuropeptides, acitretin, and patient involvement, this valuable monograph pools the insights of over 120 distinguished dermatologists on all aspects of psoriasis, detailing genetics etiology biology pathophysiology clinical manifestations pharmacology therapeutics Psoriasis, Third Edition, provides a wealth of information for practicing physicians treating patients in a clinical setting-including dermatologists, internists, rheumatologists, allergists, family physicians, pediatricians, immunologists, biochemists, radiologists, and graduate and medical students in these disciplines.       Download (23MB) Moderate-to-Severe Psoriasis, Third Edition Gastrointestinal Malignancies Drug-Induced Liver Disease Manual of Molecular and Clinical Laboratory Immunology, 8th Edition Medication Management of Chronic Pain: What You Need to Know Load more posts

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